ADC Pharmacokinetics & Clinical Pharmacology Summit 2024

Leveraging Pharmacometric Insights to Identify an Optimal Dose for ADCs that Navigates Regulatory Expectations, Threads the Needle Between Safety & Efficacy & Drives Forward BLA Approval
Event Dates
2024-10-08 - 2024-10-10
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UK: +44 (0)20 3141 8700 / US: +1 617 455 4188

Antibody‐drug conjugates (ADCs) have emerged as a rapidly evolving, highly promising class of oncology drugs, with 12 approvals and many more in development. Despite their success, the therapeutic window remains relatively narrow, posing challenges for finding an optimal dose.

In the face of evolving regulatory guidance and more complex ADCs entering development, the inaugural ADC Pharmacokinetics & Clinical Pharmacology Summit comes to life this October to provide in-depth pharmacokinetic and clinical pharmacology insights to help ADC developers select a clinical dose that maximizes efficacy whilst limiting toxicities and drive more ADCs to BLA approval quicker.

As the next generation of ADCs becomes even more complex, this further emphasizes the need for a clear strategy for those working within PK/PD, bioanalysis, pharmacometrics and clinical pharmacology to support the tricky translation from non-clinical studies into clinical trials.

See how others are approaching the early establishment of a clear mechanistic link between ADC design and PK profile, utilizing pharmacometrics and PK/PD data to inform dose optimization for FIH, later phase dosage and ADC combination therapies.

Partner Voices
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